לא צויין
נקבה
נשואה
****
אין פרטים זמינים
אין פרטים זמינים
דוקטורט
עברית
אנגלית
ערבית
רכב פרטי – רישיון ב'
רכב פרטי
Education:
2012-2016:
Post Doc- The Hebrew University of Jerusalem, Faculty of Medicine, School
of pharmacy, department of Medicinal Chemistry and Natural products
Supervisor: Prof. Raphael Mechoulam
Synthesis and evaluation of Novel cannabinoid and endocannabinoid
derivatives.
2006-2012:
PhD- The Hebrew University of Jerusalem , Faculty of Medicine, School of
pharmacy, department of Medicinal Chemistry and Natural products
Supervisor: Prof. Raphael Mechoulam
Novel cannabidiol derivatives and their use as anti-inflammatory agents.
2000-2002:
M.S.C.- The Hebrew University of Jerusalem , Faculty of Medicine, School of
pharmacy, department of Medicinal Chemistry and Natural products+
department of Pharmacology
Supervisors: Prof. Eli Breuer + Dr. Reuven Reich
Research Project: Synthesis and Evaluation of Fluorinated
Carbamoylphosphonates: Novel Matrix-Metalloproteinase Inhibitors
1997-2000:
B.S.C.- The Hebrew University of Jerusalem ,Faculty of Natural Science,
department of Chemistry, the Hebrew university of Jerusalem
השכלה
1996 - 2016
האוניברסיטה העברית בירושלים
דיפלומה
Experience:
2022-2024: Head of small molecules department in the field of ion channels.
2016-2022: Research associate, The Hebrew University of Jerusalem, Faculty of Medicine, School of Pharmacy, Institute for Drug Research.
שירות צבאי
לא שירתתי
ניסיון תעסוקתי
2016 - 2024
חוקרת באוניברסיטה העברית
מנהלת מחלקה בחברת אלומון לאב
Professional Experience:
2022-2024:
Head of small molecules department at Alomone Lab in the field of ion
channels.
The responsibilities of my job waere Business development/Product
development of the department/ Senior chemical consultant to all the
company’s departments/laboratory safety manager/responsible for
poisons, safety trusty, renewing the toxic substances and the medical toxic
substances permits
.
2005-2006:
Worked at Sigma-Aldrich Israel Ltd., Jerusalem
2002-2004:
Lab worker- The Hebrew University of Jerusalem, Faculty of Medicine,
School of pharmacy, department of Medicinal Chemistry and Natural
products.
Supervisor: Dr. Claudia Barzilay.
2001-2002:
N.M.R. instructor
2000-2001:
Instructor in Medicinal Chemistry Lab
1999-2000:
Instructor in educational project, The Hebrew university of Jerusalem
Conferences:
2000-2016:
Conference of the Israel association of medicinal chemistry.
The Israel chemical society conference.
The International Cannabinoid Research Society (ICRS).
The National Graduate Student Symposium in Organic Chemistry
(Ben-Gurion University).
Conferences of the Faculty of Medicine, School of pharmacy,
Hadassah Ein kerem.
Scholarships:
2010: The ministry of science and technology
Patents:
2018:
A patent has been registered by the Hebrew University company Yissum, a
publication has been submitted to a scientific journal.
Cannabidiolic acid esters compositions and uses thereof.
Patent number: 11440870
Cannabidiolic acid esters, compositions comprising them and uses thereof
in the treatment of various diseases, conditions and symptoms.
Publications:
Reem Smoum ,Christeene Haj ,Shira Hirsch , Alina Nemirovski , Zhannah
Yekhtin , Benny Bogoslavsky , Gaganjyot Kaur Bakshi , Mukesh Chourasia ,
Ruth Gallily , Joseph Tam , Raphael Mechoulam
Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design,
Synthesis, X-ray Structure and Therapeutic Potential
Molecules. 2022, 1382
Yong Fang Zhu, Katja Linher-Melville, Mohammad Javad Niazmand, Manu
Sharma, Ayesha Shahid, Kan Lun Zhu, Natalka Parzei, Jesse Sidhu,
Christeene Haj, Raphael Mechoulam, Gurmit Singh.
An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl
ester (CBDAME) in a preclinical model of peripheral neuropathic pain.
Br J Pharmacol. 2020; 1-30.
Hen-Shoval Danielle, Amar Shani, Shbiro Liat, Smoum Reem, Haj
Christeene, Mechoulam Raphael, Zalsman Gil, Weller Aron, Shoval Gal.
Acute oral Cannabidiolic Acid Methyl Ester reduces depression-like
behavior in two genetic animal models of depression.
Behav. Brain Res. 2018; 351: 1-3.
Pertwee RG, Rock EM, Guenther K, Limebeer CL, Stevenson LA, Haj C,
Smoum R, Parker LA, Mechoulam R.
Cannabidiolic acid methyl ester, a stable synthetic analogue of
cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of
nausea and anxiety in rats.
Br J Pharmacol. 2018; 175: 100-112.
Aviva Breuer ¶, Christeene G. Haj¶, Manoela V. Fogaça, Felipe V. Gomes,
João Francisco Pedrazzi, Elaine A. Del Bel, Jaime C. Hallak, José A. Crippa,
Antonio W. Zuardi, Raphael Mechoulam, Francisco S. Guimarães
Fluorinated cannabidiol derivatives: enhancement of activity in mice
models predictive of anxiolytic, antidepressant and antipsychotic effects
PLOS ONE. June 2016; 14: 1-19.
Ewa Kozela†, Christeene Haj†, Lumir Hanus, Mukesh Chourasia, Avital
Shurki, Ana Juknat, Nathali Kaushansky, Raphael Mechoulam and Zvi
Vogel.
HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid
Cannabidiol, Decrease the Activation of Encephalitogenic T Cells.
Chem Biol Drug Des. 2016; 87: 143–153.
Christeene G. Haj, Percy F. Sumariwalla, Lumír Hanuš, Natalya M. Kogan,
Zhana Yektin, Raphael Mechoulam, Mark Feldmann, and Ruth Gallily.
HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid.
J Pharmacol Exp Ther. 2015,355: 66-75.
Christeene G. Haj. Novel CBD derivatives and their use as anti-inflammatory
agents.
LAP LAMBERT Academic Publishing 2015
Summary:
Small molecules, new department, in Alomone Labs was established by me.
Its purpose is to organize everything related to the small molecules existing
in the company in order to expand their marketing, in addition to
developing and marketing new organic molecules that work on various ion
channels and not marketed at any other company.
A work plan, which includes the essential needs for the department, such
as: the required physical space, tools, equipment, chemicals, and relevant
instrumentation. Its goals are to recruit employees, create a work plan for
both the employee and the laboratory, which includes all the necessary
analytical and physical tests to be conducted on all products, and to find
the ideal conditions for these tests, changing the information page of the
molecules on the Alomone website, correcting the chemical and physical
information for all organic molecules, and updating the safety data sheets
for all products. Additionally, it involves searching for new suppliers for two
purposes: A. For the purchase of existing molecules, B. Development - by
expanding the company's product range,
The tests and analyses I performed:
NMR, LCMS, GCMS, MELTING POINT, POLARIMETER, SOLUBILITY,
STABILITY, TLC, UV, ELEMENTAL ANALYSIS.
The purchased instruments:
ROTAVAPOR, LCMS, SPECTROPHOTOMETER, OPTICAL ACTIVITY, MELTING
POINT, UV CABINET, SONICATOR, ANALYTICAL BALANCE, WEIGHING HOOD,
VORTEX, MINI CENTRIFUGE, LAB NITROGEN EVAPORATOR SAMPLE, HOT
PLATE WITH STIRRER.
The department has been very successful, which I led to scientific and
managerial excellence, demonstrating extensive professional knowledge
and management ability.
As a head of the small organic molecules department, the main role of my
job was Product development of the department/ Senior chemical
consultant to all the company’s departments/laboratory safety
manager/responsible for poisons, safety trusty, renewing the toxic
substances and the medical toxic substances permits.
I have contributed significantly to the development and leadership of
innovative projects, from the research stages to successful practice in the
field.
The goal was to introduce new small molecules and rare natural products
to the company that are not commercialized anywhere in the world. I
managed to achieve this goal.
As a Natural products and medicinal chemist in the field of cannabinoids
and endocannabinoids I was research associate at the Hebrew university of
Jerusalem for 17 years with expertise in multi-step synthesis, design,
development and characterization of organic compounds (NMR, LCMS,
GC…), and in experimental design techniques (chromatography) , as well as
coordinating testing and development (synthesis of derivatives and
enantiomers of cannabinoids and endocannabinoids and testing them on
many diseases like cancer, rheumatoid arthritis…) . I have much experience
in extractions of natural and biological active products from plants, such as
cannabis, and much experience in the chemical industry.
Adept at developing new applications and products, generating intellectual
properties and providing technical solutions. Practiced in instrument
monitoring and analytical methods performance (NMR, LCMS, GCMS,
Optical rotation, IR, UV).
